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Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease

Copper influences the pathogenesis of prion disease, but whether it is beneficial or detrimental remains controversial. Copper homeostasis is also essential for normal physiology, as highlighted by the spectrum of diseases caused by disruption of the copper transporting enzymes ATP7A and ATP7B. Here...

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Autori principali: Siggs, Owen M., Cruite, Justin T., Du, Xin, Rutschmann, Sophie, Masliah, Eliezer, Beutler, Bruce, Oldstone, Michael B. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427069/
https://ncbi.nlm.nih.gov/pubmed/22869751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211499109
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