A molecular mechanism of chaperone-client recognition

Por He, Lichun, Sharpe, Timothy, Mazur, Adam, Hiller, Sebastian
Publicado no Sci Adv (2016)

Distinguishing between cooperative and unimodal downhill protein folding

Por Huang, Fang, Sato, Satoshi, Sharpe, Timothy D., Ying, Liming, Fersht, Alan R.
Publicado em 2007

The human peripheral subunit-binding domain folds rapidly while overcoming repulsive Coulomb forces

Por Arbely, Eyal, Neuweiler, Hannes, Sharpe, Timothy D, Johnson, Christopher M, Fersht, Alan R
Publicado em 2010

Rapid amyloid fiber formation from the fast-folding WW domain FBP28

Por Ferguson, Neil, Berriman, John, Petrovich, Miriana, Sharpe, Timothy D., Finch, John T., Fersht, Alan R.
Publicado em 2003

Inherent Regulation of EAL Domain-catalyzed Hydrolysis of Second Messenger Cyclic di-GMP

Por Sundriyal, Amit, Massa, Claudia, Samoray, Dietrich, Zehender, Fabian, Sharpe, Timothy, Jenal, Urs, Schirmer, Tilman
Publicado em 2014

Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification

Por Stanger, Frédéric V., Burmann, Björn M., Harms, Alexander, Aragão, Hugo, Mazur, Adam, Sharpe, Timothy, Dehio, Christoph, Hiller, Sebastian, Schirmer, Tilman
Publicado no Proc Natl Acad Sci U S A (2016)

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16

Por Dixon-Clarke, Sarah E., Shehata, Saifeldin N., Krojer, Tobias, Sharpe, Timothy D., vonDelft, Frank, Sakamoto, Kei, Bullock, Alex N.
Publicado no Biochem J (2017)

The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)–fold structure

Por Adams, Cassandra J., Pike, Ashley C. W., Maniam, Sandra, Sharpe, Timothy D., Coutts, Amanda S., Knapp, Stefan, La Thangue, Nicholas B., Bullock, Alex N.
Publicado em 2012

General structural motifs of amyloid protofilaments

Por Ferguson, Neil, Becker, Johanna, Tidow, Henning, Tremmel, Sandra, Sharpe, Timothy D., Krause, Gerd, Flinders, Jeremy, Petrovich, Miriana, Berriman, John, Oschkinat, Hartmut, Fersht, Alan R.
Publicado em 2006

Structural Basis for Par-4 Recognition by the SPRY Domain- and SOCS Box-Containing Proteins SPSB1, SPSB2, and SPSB4

Por Filippakopoulos, Panagis, Low, Andrew, Sharpe, Timothy D., Uppenberg, Jonas, Yao, Shenggen, Kuang, Zhihe, Savitsky, Pavel, Lewis, Rowena S., Nicholson, Sandra E., Norton, Raymond S., Bullock, Alex N.
Publicado em 2010

Engineering Archeal Surrogate Systems for the Development of Protein–Protein Interaction Inhibitors against Human RAD51

Por Moschetti, Tommaso, Sharpe, Timothy, Fischer, Gerhard, Marsh, May E., Ng, Hong Kin, Morgan, Matthew, Scott, Duncan E., Blundell, Tom L., R. Venkitaraman, Ashok, Skidmore, John, Abell, Chris, Hyvönen, Marko
Publicado no J Mol Biol (2016)

Syrosingopine sensitizes cancer cells to killing by metformin

Por Benjamin, Don, Colombi, Marco, Hindupur, Sravanth K., Betz, Charles, Lane, Heidi A., El-Shemerly, Mahmoud Y. M., Lu, Min, Quagliata, Luca, Terracciano, Luigi, Moes, Suzette, Sharpe, Timothy, Wodnar-Filipowicz, Aleksandra, Moroni, Christoph, Hall, Michael N.
Publicado no Sci Adv (2016)