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Rapid amyloid fiber formation from the fast-folding WW domain FBP28

The WW domains are small proteins that contain a three-stranded, antiparallel β-sheet. The 40-residue murine FBP28 WW domain rapidly formed twirling ribbon-like fibrils at physiological temperature and pH, with morphology typical of amyloid fibrils. These ribbons were unusually wide and well ordered...

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Main Authors: Ferguson, Neil, Berriman, John, Petrovich, Miriana, Sharpe, Timothy D., Finch, John T., Fersht, Alan R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2003
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC187847/
https://ncbi.nlm.nih.gov/pubmed/12897238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1333907100
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