Syrosingopine sensitizes cancer cells to killing by metformin

We report that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to syrosingopine’s known role as an inhibitor...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Benjamin, Don, Colombi, Marco, Hindupur, Sravanth K., Betz, Charles, Lane, Heidi A., El-Shemerly, Mahmoud Y. M., Lu, Min, Quagliata, Luca, Terracciano, Luigi, Moes, Suzette, Sharpe, Timothy, Wodnar-Filipowicz, Aleksandra, Moroni, Christoph, Hall, Michael N.
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5182053/
https://ncbi.nlm.nih.gov/pubmed/28028542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601756
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars