Newly Identified Antibacterial Compounds Are Topoisomerase Poisons in African Trypanosomes

Por Tang, Sonya C., Shapiro, Theresa A.
Publicado em 2010

Potent Antitrypanosomal Activities of Heat Shock Protein 90 Inhibitors In Vitro and In Vivo

Por Meyer, Kirsten J., Shapiro, Theresa A.
Publicado em 2013

Antitrypanosomal Activity of Fluoroquinolones

Por Nenortas, Elizabeth, Burri, Christian, Shapiro, Theresa A.
Publicado em 1999

Model System Identifies Kinetic Driver of Hsp90 Inhibitor Activity against African Trypanosomes and Plasmodium falciparum

Por Meyer, Kirsten J., Caton, Emily, Shapiro, Theresa A.
Publicado no Antimicrob Agents Chemother (2018)

Antitrypanosomal Activities of Fluoroquinolones with Pyrrolidinyl Substitutions

Por Nenortas, Elizabeth, Kulikowicz, Tomasz, Burri, Christian, Shapiro, Theresa A.
Publicado em 2003

Targeting the gyrase of Plasmodium falciparum with topoisomerase poisons

Por Tang Girdwood, Sonya C., Nenortas, Elizabeth, Shapiro, Theresa A.
Publicado no Biochem Pharmacol (2015)

Optimal kinetic exposures for classic and candidate antitrypanosomals

Por Meyer, Kirsten J, Meyers, David J, Shapiro, Theresa A
Publicado no J Antimicrob Chemother (2019)

Hollow Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial Compounds

Por Caton, Emily, Nenortas, Elizabeth, Bakshi, Rahul P., Shapiro, Theresa A.
Publicado no Curr Protoc Chem Biol (2016)

Kinetic Driver of Antibacterial Drugs against Plasmodium falciparum and Implications for Clinical Dosing

Por Caton, Emily, Nenortas, Elizabeth, Bakshi, Rahul P., Shapiro, Theresa A.
Publicado no Antimicrob Agents Chemother (2019)

Activity of Indenoisoquinolines against African Trypanosomes

Por Bakshi, Rahul P., Sang, Dongpei, Morrell, Andrew, Cushman, Mark, Shapiro, Theresa A.
Publicado em 2009

An unusual type IB topoisomerase from African trypanosomes

Por Bodley, Annette L., Chakraborty, Asit K., Xie, Suji, Burri, Christian, Shapiro, Theresa A.
Publicado em 2003

Antimalarial Preclinical Drug Development: A Single Oral Dose of A 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice

Por Moon, Deuk Kyu, Singhal, Vandana, Kumar, Nirbhay, Shapiro, Theresa A., Posner, Gary H.
Publicado em 2009

Phase I/II Evaluation of the Prophylactic Antimalarial Activity of Pafuramidine in Healthy Volunteers Challenged with Plasmodium falciparum Sporozoites

Por Nyunt, Myaing M., Hendrix, Craig W., Bakshi, Rahul P, Kumar, Nirbhay, Shapiro, Theresa A.
Publicado em 2009

Model System to Define Pharmacokinetic Requirements for Antimalarial Drug Efficacy

Por Bakshi, Rahul P., Nenortas, Elizabeth, Tripathi, Abhai K., Sullivan, David J., Shapiro, Theresa A.
Publicado em 2013

Semi-quantitative measurement of the antimalarial lumefantrine from untreated dried blood spots using LC-MS/MS

Por Ippolito, Matthew M., Huang, Liusheng, Siame, Mwiche, Thuma, Philip, Shapiro, Theresa A., Aweeka, Francesca T.
Publicado no J Pharm Biomed Anal (2018)

Activity of Aromathecins against African Trypanosomes

Por Nenortas, Nathaniel P., Cinelli, Maris A., Morrell, Andrew E., Cushman, Mark, Shapiro, Theresa A.
Publicado no Antimicrob Agents Chemother (2018)

Evidence of Microbiome–Drug Interaction between the Antimalarial Lumefantrine and Gut Microbiota in Mice

Por Ippolito, Matthew M., Denny, Joshua E., Nenortas, Elizabeth, Shapiro, Theresa A., Schmidt, Nathan W.
Publicado no Am J Trop Med Hyg (2020)

Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine

Por Woodard, Lauren E., Mott, Bryan T., Singhal, Vandana, Kumar, Nirbhay, Shapiro, Theresa A., Posner, Gary H.
Publicado em 2009

Malaria-Infected Mice Live Until At Least Day 30 After A New Monomeric Trioxane Combined with Mefloquine Are Administered Together In A Single Low Oral Dose

Por Woodard, Lauren E., Chang, Wonsuk, Chen, Xiaochun, Liu, Jun O., Shapiro, Theresa A., Posner, Gary H.
Publicado em 2009

Membrane active chelators as novel anti-African trypanosome and anti-malarial drugs

Por Grab, Dennis J., Nenortas, Elizabeth, Bakshi, Rahul, Nikolskaia, Olga V., Friedman, Jonathan E., Shapiro, Theresa A.
Publicado em 2013