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Activity of Aromathecins against African Trypanosomes

African sleeping sickness is responsible for thousands of deaths annually, and new therapeutics are needed. This study evaluated aromathecins, experimental inhibitors of mammalian topoisomerase IB, against Trypanosoma brucei African trypanosomes. The compounds had selectively toxic antiparasitic pot...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Nenortas, Nathaniel P., Cinelli, Maris A., Morrell, Andrew E., Cushman, Mark, Shapiro, Theresa A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201061/
https://ncbi.nlm.nih.gov/pubmed/30104277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00786-18
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