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Targeting the gyrase of Plasmodium falciparum with topoisomerase poisons

Drug-resistant malaria poses a major public health problem throughout the world and the need for new antimalarial drugs is growing. The apicoplast, a chloroplast-like organelle essential for malaria parasite survival and with no counterpart in humans, offers an attractive target for selectively toxi...

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Détails bibliographiques
Publié dans:Biochem Pharmacol
Auteurs principaux: Tang Girdwood, Sonya C., Nenortas, Elizabeth, Shapiro, Theresa A.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449814/
https://ncbi.nlm.nih.gov/pubmed/25881748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.03.018
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