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Bimodal actions of a naphthyridone/aminopiperidine-based antibacterial that targets gyrase and topoisomerase IV

Gyrase and topoisomerase IV are the targets of fluoroquinolone antibacterials. However, the rise in antimicrobial resistance has undermined the clinical use of this important drug class. Therefore, it is critical to identify new agents that maintain activity against fluoroquinolone-resistant strains...

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Foilsithe in:Biochemistry
Main Authors: Gibson, Elizabeth G., Oviatt, Alexandria A., Cacho, Monica, Neuman, Keir C., Chan, Pan F., Osheroff, Neil
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450530/
https://ncbi.nlm.nih.gov/pubmed/31617352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00805
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