Single-molecule Measurements of DNA Topology and Topoisomerases

Por Neuman, Keir C.
Publicado em 2010

Evolutionary twist on topoisomerases: Conversion of gyrase to topoisomerase IV

Por Neuman, Keir C.
Publicado em 2010

The tail that wags the dog: Topoisomerase IV ParC C-Terminal domain controls strand passage activity through multipartite topology-dependent interactions with DNA

Por Neuman, Keir C.
Publicado em 2013

Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy

Por Neuman, Keir C., Nagy, Attila
Publicado em 2008

The dynamic interplay between DNA topoisomerases and DNA topology

Por Seol, Yeonee, Neuman, Keir C.
Publicado no Biophys Rev (2016)

The dynamic interplay between DNA topoisomerases and DNA topology

Por Seol, Yeonee, Neuman, Keir C.
Publicado no Biophys Rev (2016)

Combined magnetic tweezers and micro-mirror total internal reflection fluorescence microscope for single molecule manipulation and visualization

Por Seol, Yeonee, Neuman, Keir C.
Publicado no Methods Mol Biol (2018)

Optical trapping

Por Neuman, Keir C., Block, Steven M.
Publicado em 2004

A propagating ATPase gradient drives transport of surface-confined cellular cargo

Por Vecchiarelli, Anthony G., Neuman, Keir C., Mizuuchi, Kiyoshi
Publicado em 2014

Single molecule measurements of DNA helicase activity with magnetic tweezers and t-test based step-finding analysis

Por Seol, Yeonee, Strub, Marie-Paule, Neuman, Keir C.
Publicado no Methods (2016)

Measurement of the effective focal shift in an optical trap

Por Neuman, Keir C., Abbondanzieri, Elio A., Block, Steven M.
Publicado em 2005

A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity

Por Seol, Yeonee, Zhang, Hongliang, Pommier, Yves, Neuman, Keir C.
Publicado em 2012

Single-molecule Tracking of Collagenase on Native Type I Collagen Fibrils Reveals Degradation Mechanism

Por Sarkar, Susanta K., Marmer, Barry, Goldberg, Gregory, Neuman, Keir C.
Publicado em 2012

Chiral Discrimination and Writhe-dependent Relaxation Mechanism of Human Topoisomerase IIα

Por Seol, Yeonee, Gentry, Amanda C., Osheroff, Neil, Neuman, Keir C.
Publicado em 2013

A moving ParA gradient on the nucleoid directs subcellular cargo transport via a chemophoresis force

Por Vecchiarelli, Anthony G, Seol, Yeonee, Neuman, Keir C, Mizuuchi, Kiyoshi
Publicado no Bioarchitecture (2015)

A robust assay to measure DNA topology-dependent protein binding affinity

Por Litwin, Tamara R., Solà, Maria, Holt, Ian J., Neuman, Keir C.
Publicado no Nucleic Acids Res (2015)

Distribution bias and biochemical characterization of TOP1MT single nucleotide variants

Por Zhang, Hongliang, Seol, Yeonee, Agama, Keli, Neuman, Keir C., Pommier, Yves
Publicado no Sci Rep (2017)

The HRDC domain of E. coli RecQ helicase controls single-stranded DNA translocation and double-stranded DNA unwinding rates without affecting mechanoenzymatic coupling

Por Harami, Gábor M., Nagy, Nikolett T., Martina, Máté, Neuman, Keir C., Kovács, Mihály
Publicado no Sci Rep (2015)

Directed and persistent movement arises from mechanochemistry of the ParA/ParB system

Por Hu, Longhua, Vecchiarelli, Anthony G., Mizuuchi, Kiyoshi, Neuman, Keir C., Liu, Jian
Publicado no Proc Natl Acad Sci U S A (2015)

Brownian Ratchet Mechanism for Faithful Segregation of Low-Copy-Number Plasmids

Por Hu, Longhua, Vecchiarelli, Anthony G., Mizuuchi, Kiyoshi, Neuman, Keir C., Liu, Jian
Publicado no Biophys J (2017)