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A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity
Type IB topoisomerases (Top1Bs) relax excessive DNA supercoiling associated with replication and transcription by catalyzing a transient nick in one strand to permit controlled rotation of the DNA about the intact strand. The natural compound camptothecin (CPT) and the cancer chemotherapeutics deriv...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3479559/ https://ncbi.nlm.nih.gov/pubmed/22991469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206480109 |
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