A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity

Type IB topoisomerases (Top1Bs) relax excessive DNA supercoiling associated with replication and transcription by catalyzing a transient nick in one strand to permit controlled rotation of the DNA about the intact strand. The natural compound camptothecin (CPT) and the cancer chemotherapeutics deriv...

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Bibliographic Details
Main Authors: Seol, Yeonee, Zhang, Hongliang, Pommier, Yves, Neuman, Keir C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479559/
https://ncbi.nlm.nih.gov/pubmed/22991469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206480109
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