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Distribution bias and biochemical characterization of TOP1MT single nucleotide variants

Mitochondrial topoisomerase I (TOP1MT) is a type IB topoisomerase encoded in the nucleus of vertebrate cells. In contrast to the other five human topoisomerases, TOP1MT possesses two high frequency single nucleotide variants (SNVs), rs11544484 (V256I, Minor Allele Frequency = 0.27) and rs2293925 (R5...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Zhang, Hongliang, Seol, Yeonee, Agama, Keli, Neuman, Keir C., Pommier, Yves
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561071/
https://ncbi.nlm.nih.gov/pubmed/28819183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09258-2
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