Mapping Topoisomerase Sites in Mitochondrial DNA with a Poisonous Mitochondrial Topoisomerase I (Top1mt)

Mitochondrial topoisomerase I (Top1mt) is a type IB topoisomerase present in vertebrates and exclusively targeted to mitochondria. Top1mt relaxes mitochondrial DNA (mtDNA) supercoiling by introducing transient cleavage complexes wherein the broken DNA strand swivels around the intact strand. Top1mt...

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Bibliografiska uppgifter
Huvudupphovsmän: Dalla Rosa, Ilaria, Huang, Shar-yin N., Agama, Keli, Khiati, Salim, Zhang, Hongliang, Pommier, Yves
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
DNA and Chromosomes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140277/
https://ncbi.nlm.nih.gov/pubmed/24798329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.555367
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