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Transcription profiling suggests that mitochondrial topoisomerase IB acts as a topological barrier and regulator of mitochondrial DNA transcription

Mitochondrial DNA (mtDNA) is essential for cell viability because it encodes subunits of the respiratory chain complexes. Mitochondrial topoisomerase IB (TOP1MT) facilitates mtDNA replication by removing DNA topological tensions produced during mtDNA transcription, but it appears to be dispensable....

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Dalla Rosa, Ilaria, Zhang, Hongliang, Khiati, Salim, Wu, Xiaolin, Pommier, Yves
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724003/
https://ncbi.nlm.nih.gov/pubmed/29021209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.815241
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