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Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC

Mitochondrial DNA (mtDNA) is entirely dependent on nuclear genes for its transcription and replication. One of these genes is TOP1MT, which encodes the mitochondrial DNA topoisomerase IB, involved in mtDNA relaxation. To elucidate TOP1MT regulation, we performed genome-wide profiling across the 60-c...

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Detalhes bibliográficos
Main Authors: Zoppoli, Gabriele, Douarre, Céline, Dalla Rosa, Ilaria, Liu, Hongfang, Reinhold, William, Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159436/
https://ncbi.nlm.nih.gov/pubmed/21531700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr208
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