Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

BACKGROUND: Mitochondria contain their own DNA genome (mtDNA), as well as specific DNA replication and protein synthesis machineries. Relaxation of the circular, double-stranded mtDNA relies on the presence of topoisomerase activity. Three different topoisomerases have been identified in mitochondri...

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Autores principales: Douarre, Céline, Sourbier, Carole, Dalla Rosa, Ilaria, Brata Das, Benu, Redon, Christophe E., Zhang, Hongliang, Neckers, Len, Pommier, Yves
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401127/
https://ncbi.nlm.nih.gov/pubmed/22911747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041094
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