Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA

Topoisomerase I is essential for DNA metabolism in nuclei and mitochondria. In yeast, a single topoisomerase I gene provides for both organelles. In vertebrates, topoisomerase I is divided into nuclear and mitochondrial paralogs (Top1 and Top1mt). To assess the meaning of this gene duplication, we t...

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Bibliographic Details
Main Authors: Rosa, Ilaria Dalla, Goffart, Steffi, Wurm, Melanie, Wiek, Constanze, Essmann, Frank, Sobek, Stefan, Schroeder, Peter, Zhang, Hongliang, Krutmann, Jean, Hanenberg, Helmut, Schulze-Osthoff, Klaus, Mielke, Christian, Pommier, Yves, Boege, Fritz, Christensen, Morten O.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770673/
https://ncbi.nlm.nih.gov/pubmed/19720733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp708
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