Twist and Turn—Topoisomerase Functions in Mitochondrial DNA Maintenance

per Goffart, Steffi, Hangas, Anu, Pohjoismäki, Jaakko L. O.
Publicat a Int J Mol Sci (2019)

Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shi...

per Torregrosa-Muñumer, Rubén, Goffart, Steffi, Haikonen, Juha A., Pohjoismäki, Jaakko L. O.
Publicat a Mol Biol Cell (2015)

The Type and Source of Reactive Oxygen Species Influences the Outcome of Oxidative Stress in Cultured Cells

per Goffart, Steffi, Tikkanen, Petra, Michell, Craig, Wilson, Trevor, Pohjoismäki, Jaakko L. O.
Publicat a Cells (2021)

Transient overexpression of mitochondrial transcription factor A (TFAM) is sufficient to stimulate mitochondrial DNA transcription, but not sufficient to increase mtDNA copy number...

per Maniura-Weber, Katharina, Goffart, Steffi, Garstka, Heike L., Montoya, Julio, Wiesner, Rudolf J.
Publicat 2004

Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes

per Wanrooij, Sjoerd, Goffart, Steffi, Pohjoismäki, Jaakko L.O., Yasukawa, Takehiro, Spelbrink, Johannes N.
Publicat 2007

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

per Goffart, Steffi, Cooper, Helen M., Tyynismaa, Henna, Wanrooij, Sjoerd, Suomalainen, Anu, Spelbrink, Johannes N.
Publicat 2009

Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response

per Pohjoismäki, Jaakko L. O., Boettger, Thomas, Liu, Zhipei, Goffart, Steffi, Szibor, Marten, Braun, Thomas
Publicat 2012

Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2

per Hangas, Anu, Aasumets, Koit, Kekäläinen, Nina J, Paloheinä, Mika, Pohjoismäki, Jaakko L, Gerhold, Joachim M, Goffart, Steffi
Publicat a Nucleic Acids Res (2018)

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells

per Pohjoismäki, Jaakko L. O., Wanrooij, Sjoerd, Hyvärinen, Anne K., Goffart, Steffi, Holt, Ian J., Spelbrink, Johannes N., Jacobs, Howard T.
Publicat 2006

CREB-1α Is Recruited to and Mediates Upregulation of the Cytochrome c Promoter during Enhanced Mitochondrial Biogenesis Accompanying Skeletal Muscle Differentiation

per Franko, Andras, Mayer, Sabine, Thiel, Gerald, Mercy, Ludovic, Arnould, Thierry, Hornig-Do, Hue-Tran, Wiesner, Rudolf J., Goffart, Steffi
Publicat 2008

Developmental and Pathological Changes in the Human Cardiac Muscle Mitochondrial DNA Organization, Replication and Copy Number

per Pohjoismäki, Jaakko L. O., Goffart, Steffi, Taylor, Robert W., Turnbull, Douglas M., Suomalainen, Anu, Jacobs, Howard T., Karhunen, Pekka J.
Publicat 2010

Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species

per Pohjoismäki, Jaakko L. O., Williams, Siôn L., Boettger, Thomas, Goffart, Steffi, Kim, Johnny, Suomalainen, Anu, Moraes, Carlos T., Braun, Thomas
Publicat 2013

Replication fork rescue in mammalian mitochondria

per Torregrosa-Muñumer, Rubén, Hangas, Anu, Goffart, Steffi, Blei, Daniel, Zsurka, Gábor, Griffith, Jack, Kunz, Wolfram S., Pohjoismäki, Jaakko L. O.
Publicat a Sci Rep (2019)

ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels

per Peralta, Susana, Goffart, Steffi, Williams, Sion L., Diaz, Francisca, Garcia, Sofia, Nissanka, Nadee, Area-Gomez, Estela, Pohjoismäki, Jaakko, Moraes, Carlos T.
Publicat a J Cell Sci (2018)

PrimPol is required for replication reinitiation after mtDNA damage

per Torregrosa-Muñumer, Rubén, Forslund, Josefin M. E., Goffart, Steffi, Pfeiffer, Annika, Stojkovič, Gorazd, Carvalho, Gustavo, Al-Furoukh, Natalie, Blanco, Luis, Wanrooij, Sjoerd, Pohjoismäki, Jaakko L. O.
Publicat a Proc Natl Acad Sci U S A (2017)

Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks

per Pohjoismäki, Jaakko L. O., Goffart, Steffi, Tyynismaa, Henna, Willcox, Smaranda, Ide, Tomomi, Kang, Dongchon, Suomalainen, Anu, Karhunen, Pekka J., Griffith, Jack D., Holt, Ian J., Jacobs, Howard T.
Publicat 2009

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA

per Rosa, Ilaria Dalla, Goffart, Steffi, Wurm, Melanie, Wiek, Constanze, Essmann, Frank, Sobek, Stefan, Schroeder, Peter, Zhang, Hongliang, Krutmann, Jean, Hanenberg, Helmut, Schulze-Osthoff, Klaus, Mielke, Christian, Pommier, Yves, Boege, Fritz, Christensen, Morten O.
Publicat 2009

Mammalian mitochondrial DNA replication intermediates are essentially duplex, but contain extensive tracts of RNA/DNA hybrid

per Pohjoismäki, Jaakko L. O., Holmes, J. Bradley, Wood, Stuart R., Yang, Ming-Yao, Yasukawa, Takehiro, Reyes, Aurelio, Laura, J. Bailey, Cluett, Tricia J., Goffart, Steffi, Willcox, Smaranda, Rigby, Rachel E., Jackson, Andrew P., Spelbrink, Johannes N., Griffith, Jack D., Crouch, Robert J., Jacobs, Howard T., Holt, Ian J.
Publicat 2010

Preclinical Efficacy and Safety Evaluation of Hematopoietic Stem Cell Gene Therapy in a Mouse Model of MNGIE

per Yadak, Rana, Cabrera-Pérez, Raquel, Torres-Torronteras, Javier, Bugiani, Marianna, Haeck, Joost C., Huston, Marshall W., Bogaerts, Elly, Goffart, Steffi, Jacobs, Edwin H., Stok, Merel, Leonardelli, Lorena, Biasco, Luca, Verdijk, Robert M., Bernsen, Monique R., Ruijter, George, Martí, Ramon, Wagemaker, Gerard, van Til, Niek P., de Coo, Irenaeus F.M.
Publicat a Mol Ther Methods Clin Dev (2018)