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Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2

Maintenance of topological homeostasis is vital for gene expression and genome replication in all organisms. Similar to other circular genomes, also mitochondrial DNA (mtDNA) is known to exist in various different topological forms, although their functional significance remains unknown. We report h...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Hangas, Anu, Aasumets, Koit, Kekäläinen, Nina J, Paloheinä, Mika, Pohjoismäki, Jaakko L, Gerhold, Joachim M, Goffart, Steffi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182158/
https://ncbi.nlm.nih.gov/pubmed/30169847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky793
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