Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2

Maintenance of topological homeostasis is vital for gene expression and genome replication in all organisms. Similar to other circular genomes, also mitochondrial DNA (mtDNA) is known to exist in various different topological forms, although their functional significance remains unknown. We report h...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Hangas, Anu, Aasumets, Koit, Kekäläinen, Nina J, Paloheinä, Mika, Pohjoismäki, Jaakko L, Gerhold, Joachim M, Goffart, Steffi
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
Предметы:
Nucleic Acid Enzymes
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182158/
https://ncbi.nlm.nih.gov/pubmed/30169847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky793
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