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Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response

Cardiomyocyte development in mammals is characterized by a transition from hyperplastic to hypertrophic growth soon after birth. The rise of cardiomyocyte cell mass in postnatal life goes along with a proportionally bigger increase in the mitochondrial mass in response to growing energy requirements...

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Bibliografski detalji
Glavni autori: Pohjoismäki, Jaakko L. O., Boettger, Thomas, Liu, Zhipei, Goffart, Steffi, Szibor, Marten, Braun, Thomas
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413112/
https://ncbi.nlm.nih.gov/pubmed/22508755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks301
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