ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels

Mutations in the mitochondrial inner membrane ATPase ATAD3A result in neurological syndromes in humans. In mice, the ubiquitous disruption of Atad3 (also known as Atad3a) was embryonic lethal, but a skeletal muscle-specific conditional knockout (KO) was viable. At birth, ATAD3 muscle KO mice had nor...

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Veröffentlicht in:J Cell Sci
Hauptverfasser: Peralta, Susana, Goffart, Steffi, Williams, Sion L., Diaz, Francisca, Garcia, Sofia, Nissanka, Nadee, Area-Gomez, Estela, Pohjoismäki, Jaakko, Moraes, Carlos T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6051345/
https://ncbi.nlm.nih.gov/pubmed/29898916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.217075
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