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Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells

Mitochondrial transcription factor A (TFAM) is an abundant mitochondrial protein of the HMG superfamily, with various putative roles in mitochondrial DNA (mtDNA) metabolism. In this study we have investigated the effects on mtDNA replication of manipulating TFAM expression in cultured human cells. M...

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Detalhes bibliográficos
Main Authors: Pohjoismäki, Jaakko L. O., Wanrooij, Sjoerd, Hyvärinen, Anne K., Goffart, Steffi, Holt, Ian J., Spelbrink, Johannes N., Jacobs, Howard T.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635303/
https://ncbi.nlm.nih.gov/pubmed/17062618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl703
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