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C-Terminal regions of topoisomerase IIα and IIβ determine isoform-specific functioning of the enzymes in vivo
Topoisomerase II removes supercoils and catenanes generated during DNA metabolic processes such as transcription and replication. Vertebrate cells express two genetically distinct isoforms (α and β) with similar structures and biochemical activities but different biological roles. Topoisomerase IIα...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1920234/ https://ncbi.nlm.nih.gov/pubmed/17526531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm102 |
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