C-Terminal regions of topoisomerase IIα and IIβ determine isoform-specific functioning of the enzymes in vivo

Topoisomerase II removes supercoils and catenanes generated during DNA metabolic processes such as transcription and replication. Vertebrate cells express two genetically distinct isoforms (α and β) with similar structures and biochemical activities but different biological roles. Topoisomerase IIα...

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Main Authors: Linka, René M., Porter, Andrew C.G., Volkov, Arsen, Mielke, Christian, Boege, Fritz, Christensen, Morten O.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2007
Ábhair:
Molecular Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1920234/
https://ncbi.nlm.nih.gov/pubmed/17526531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm102
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