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C-Terminal regions of topoisomerase IIα and IIβ determine isoform-specific functioning of the enzymes in vivo
Topoisomerase II removes supercoils and catenanes generated during DNA metabolic processes such as transcription and replication. Vertebrate cells express two genetically distinct isoforms (α and β) with similar structures and biochemical activities but different biological roles. Topoisomerase IIα...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1920234/ https://ncbi.nlm.nih.gov/pubmed/17526531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm102 |
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