The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells

As proliferating cells transit from interphase into M-phase, chromatin undergoes extensive reorganization, and topoisomerase (topo) IIα, the major isoform of this enzyme present in cycling vertebrate cells, plays a key role in this process. In this study, a human cell line conditional null mutant fo...

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Bibliografiske detaljer
Main Authors: Farr, Christine J., Antoniou-Kourounioti, Melissa, Mimmack, Michael L., Volkov, Arsen, Porter, Andrew C. G.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985649/
https://ncbi.nlm.nih.gov/pubmed/24476913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku076
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