C-Terminal regions of topoisomerase IIα and IIβ determine isoform-specific functioning of the enzymes in vivo

Topoisomerase II removes supercoils and catenanes generated during DNA metabolic processes such as transcription and replication. Vertebrate cells express two genetically distinct isoforms (α and β) with similar structures and biochemical activities but different biological roles. Topoisomerase IIα...

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Detalles Bibliográficos
Autores principales: Linka, René M., Porter, Andrew C.G., Volkov, Arsen, Mielke, Christian, Boege, Fritz, Christensen, Morten O.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1920234/
https://ncbi.nlm.nih.gov/pubmed/17526531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm102
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