Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint

Topoisomerase (topo) IIα and IIβ maintain genome stability and are targets for anti-tumor drugs. In this study, we demonstrate that the decatenation checkpoint is regulated, not only by topo IIα, as previously reported, but also by topo IIβ. The decatenation checkpoint is most efficient when both is...

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Publicat a:Nucleic Acids Res
Autors principals: Kozuki, Toshiyuki, Chikamori, Kenichi, Surleac, Marius D., Micluta, Marius A., Petrescu, Andrei J., Norris, Eric J., Elson, Paul, Hoeltge, Gerald A., Grabowski, Dale R., Porter, Andrew C.G., Ganapathi, Ram N., Ganapathi, Mahrukh K.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Nucleic Acid Enzymes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449615/
https://ncbi.nlm.nih.gov/pubmed/28472494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx325
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