Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint

Topoisomerase (topo) IIα and IIβ maintain genome stability and are targets for anti-tumor drugs. In this study, we demonstrate that the decatenation checkpoint is regulated, not only by topo IIα, as previously reported, but also by topo IIβ. The decatenation checkpoint is most efficient when both is...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Kozuki, Toshiyuki, Chikamori, Kenichi, Surleac, Marius D., Micluta, Marius A., Petrescu, Andrei J., Norris, Eric J., Elson, Paul, Hoeltge, Gerald A., Grabowski, Dale R., Porter, Andrew C.G., Ganapathi, Ram N., Ganapathi, Mahrukh K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2017
Pynciau:
Nucleic Acid Enzymes
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449615/
https://ncbi.nlm.nih.gov/pubmed/28472494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx325
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