Tyrosine 656 in topoisomerase IIβ is important for the catalytic activity of the enzyme: Identification based on artifactual +80-Da modification at this site

Topoisomerase (topo) II catalyzes topological changes in DNA. Although both human isozymes, topo IIα and β are phosphorylated, site-specific phosphorylation of topo IIβ is poorly characterized. Using LC-MS/MS analysis of topo IIβ, cleaved with trypsin, Arg C or cyanogen bromide (CNBr) plus trypsin,...

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Main Authors: Grozav, Adrian G., Willard, Belinda B., Kozuki, Toshiyuki, Chikamori, Kenichi, Micluta, Marius A., Petrescu, Andrei-Jose, Kinter, Michael, Ganapathi, Ram, Ganapathi, Mahrukh K.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608106/
https://ncbi.nlm.nih.gov/pubmed/21280220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201000194
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