Casein kinase I δ/ɛ phosphorylates topoisomerase IIα at serine-1106 and modulates DNA cleavage activity

We previously reported that phosphorylation of topoisomerase (topo) IIα at serine-1106 (Ser-1106) regulates enzyme activity and sensitivity to topo II-targeted drugs. In this study we demonstrate that phosphorylation of Ser-1106, which is flanked by acidic amino acids, is regulated in vivo by casein...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Grozav, Adrian G., Chikamori, Kenichi, Kozuki, Toshiyuki, Grabowski, Dale R., Bukowski, Ronald M., Willard, Belinda, Kinter, Michael, Andersen, Anni H., Ganapathi, Ram, Ganapathi, Mahrukh K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2009
Konular:
Nucleic Acid Enzymes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632902/
https://ncbi.nlm.nih.gov/pubmed/19043076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn934
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller