Casein kinase I δ/ɛ phosphorylates topoisomerase IIα at serine-1106 and modulates DNA cleavage activity

We previously reported that phosphorylation of topoisomerase (topo) IIα at serine-1106 (Ser-1106) regulates enzyme activity and sensitivity to topo II-targeted drugs. In this study we demonstrate that phosphorylation of Ser-1106, which is flanked by acidic amino acids, is regulated in vivo by casein...

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Detalhes bibliográficos
Main Authors: Grozav, Adrian G., Chikamori, Kenichi, Kozuki, Toshiyuki, Grabowski, Dale R., Bukowski, Ronald M., Willard, Belinda, Kinter, Michael, Andersen, Anni H., Ganapathi, Ram, Ganapathi, Mahrukh K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632902/
https://ncbi.nlm.nih.gov/pubmed/19043076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn934
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