Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC

Mitochondrial DNA (mtDNA) is entirely dependent on nuclear genes for its transcription and replication. One of these genes is TOP1MT, which encodes the mitochondrial DNA topoisomerase IB, involved in mtDNA relaxation. To elucidate TOP1MT regulation, we performed genome-wide profiling across the 60-c...

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Bibliografiske detaljer
Main Authors: Zoppoli, Gabriele, Douarre, Céline, Dalla Rosa, Ilaria, Liu, Hongfang, Reinhold, William, Pommier, Yves
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159436/
https://ncbi.nlm.nih.gov/pubmed/21531700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr208
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