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Chiral Discrimination and Writhe-dependent Relaxation Mechanism of Human Topoisomerase IIα
Type IIA topoisomerases (Topo IIA) are essential enzymes that relax DNA supercoils and remove links joining replicated chromosomes. Human topoisomerase IIα (htopo IIα), one of two human isoforms, preferentially relaxes positive supercoils, a feature shared with Escherichia coli topoisomerase IV (Top...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650406/ https://ncbi.nlm.nih.gov/pubmed/23508957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.444745 |
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