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Mechanisms of chiral discrimination by topoisomerase IV
Topoisomerase IV (Topo IV), an essential ATP-dependent bacterial type II topoisomerase, transports one segment of DNA through a transient double-strand break in a second segment of DNA. In vivo, Topo IV unlinks catenated chromosomes before cell division and relaxes positive supercoils generated duri...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2667371/ https://ncbi.nlm.nih.gov/pubmed/19359479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900574106 |
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