Mechanisms of chiral discrimination by topoisomerase IV

Topoisomerase IV (Topo IV), an essential ATP-dependent bacterial type II topoisomerase, transports one segment of DNA through a transient double-strand break in a second segment of DNA. In vivo, Topo IV unlinks catenated chromosomes before cell division and relaxes positive supercoils generated duri...

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Bibliographic Details
Main Authors: Neuman, K. C., Charvin, G., Bensimon, D., Croquette, V.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667371/
https://ncbi.nlm.nih.gov/pubmed/19359479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900574106
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