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Antitrypanosomal Activities of Fluoroquinolones with Pyrrolidinyl Substitutions
Fluoroquinolones with pyrrolidinyl substitutions were tested against Trypanosoma brucei and mammalian cells. Bulky substituents at C-7 or a 1-2-bridging thiazolidine ring increased antitrypanosomal activity and selective toxicity. These compounds trap protein-DNA complexes and inhibit nucleic acid b...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC182618/ https://ncbi.nlm.nih.gov/pubmed/12937017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.9.3015-3017.2003 |
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