Antitrypanosomal Activities of Fluoroquinolones with Pyrrolidinyl Substitutions
Fluoroquinolones with pyrrolidinyl substitutions were tested against Trypanosoma brucei and mammalian cells. Bulky substituents at C-7 or a 1-2-bridging thiazolidine ring increased antitrypanosomal activity and selective toxicity. These compounds trap protein-DNA complexes and inhibit nucleic acid b...
Збережено в:
| Опубліковано в:: | Antimicrob Agents Chemother |
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| Автори: | , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
American Society for Microbiology (ASM)
2003
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC182618/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12937017/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.9.3015-3017.2003 |
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