Antitrypanosomal Activities of Fluoroquinolones with Pyrrolidinyl Substitutions

Fluoroquinolones with pyrrolidinyl substitutions were tested against Trypanosoma brucei and mammalian cells. Bulky substituents at C-7 or a 1-2-bridging thiazolidine ring increased antitrypanosomal activity and selective toxicity. These compounds trap protein-DNA complexes and inhibit nucleic acid b...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Nenortas, Elizabeth, Kulikowicz, Tomasz, Burri, Christian, Shapiro, Theresa A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Susceptibility
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC182618/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12937017/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.9.3015-3017.2003
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