The role of animal models in advancing amyloid-beta immunotherapy to the clinic

Por Games, Dora, Seubert, Peter
Publicado em 2010

Amyloid-β neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity

Por Malinin, Nikolay L., Wright, Sarah, Seubert, Peter, Schenk, Dale, Griswold-Prenner, Irene
Publicado em 2005

Evidence that the 42- and 40-amino acid forms of amyloid β protein are generated from the β-amyloid precursor protein by different protease activities

Por Citron, Martin, Diehl, Thekla S., Gordon, Grace, Biere, Anja Leona, Seubert, Peter, Selkoe, Dennis J.
Publicado em 1996

Increased T Cell Recruitment to the CNS after Amyloid β(1–42) Immunization in Alzheimer's Mice Overproducing Transforming Growth Factor-β1

Por Buckwalter, Marion S., Coleman, Bronwen S., Buttini, Manuel, Barbour, Robin, Schenk, Dale, Games, Dora, Seubert, Peter, Wyss-Coray, Tony
Publicado em 2006

Amyloid-beta inhibits E-S Potentiation through suppression of cannabinoid receptor 1-dependent synaptic disinhibition

Por Orr, Adrienne L., Hanson, Jesse E., Li, Dong, Klotz, Adam, Wright, Sarah, Schenk, Dale, Seubert, Peter, Madison, Daniel V.
Publicado em 2014

Morphological Characterization of Thioflavin-S-Positive Amyloid Plaques in Transgenic Alzheimer Mice and Effect of Passive Aβ Immunotherapy on Their Clearance

Por Bussière, Thierry, Bard, Frédérique, Barbour, Robin, Grajeda, Henry, Guido, Terry, Khan, Karen, Schenk, Dale, Games, Dora, Seubert, Peter, Buttini, Manuel
Publicado em 2004

AL Amyloid Imaging and Therapy with a Monoclonal Antibody to a Cryptic Epitope on Amyloid Fibrils

Por Wall, Jonathan S., Kennel, Stephen J., Williams, Angela, Richey, Tina, Stuckey, Alan, Huang, Ying, Macy, Sallie, Donnell, Robert, Barbour, Robin, Seubert, Peter, Schenk, Dale
Publicado em 2012

Generation and Characterization of Anti-AA Amyloid-Specific Monoclonal Antibodies

Por Wall, Jonathan S., Kennel, Stephen J., Richey, Tina, Allen, Amy, Stuckey, Alan, Weiss, Deborah T., Macy, Sallie D., Barbour, Robin, Seubert, Peter, Solomon, Alan, Schenk, Dale
Publicado em 2011

Axonopathy in an α-Synuclein Transgenic Model of Lewy Body Disease Is Associated with Extensive Accumulation of C-Terminal–Truncated α-Synuclein

Por Games, Dora, Seubert, Peter, Rockenstein, Edward, Patrick, Christina, Trejo, Margarita, Ubhi, Kiren, Ettle, Benjamin, Ghassemiam, Majid, Barbour, Robin, Schenk, Dale, Nuber, Silke, Masliah, Eliezer
Publicado em 2013

Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy

Por Spencer, Brian, Valera, Elvira, Rockenstein, Edward, Overk, Cassia, Mante, Michael, Adame, Anthony, Zago, Wagner, Seubert, Peter, Barbour, Robin, Schenk, Dale, Games, Dora, Rissman, Robert A., Masliah, Eliezer
Publicado no Acta Neuropathol Commun (2017)

Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity

Por Welzel, Alfred T., Maggio, John E., Shankar, Ganesh M., Walker, Donald E., Ostaszewski, Beth L., Li, Shaomin, Klyubin, Igor, Rowan, Michael J., Seubert, Peter, Walsh, Dominic M., Selkoe, Dennis J.
Publicado em 2014

Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models

Por Games, Dora, Valera, Elvira, Spencer, Brian, Rockenstein, Edward, Mante, Michael, Adame, Anthony, Patrick, Christina, Ubhi, Kiren, Nuber, Silke, Sacayon, Patricia, Zago, Wagner, Seubert, Peter, Barbour, Robin, Schenk, Dale, Masliah, Eliezer
Publicado em 2014

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

Por Masliah, Eliezer, Rockenstein, Edward, Mante, Michael, Crews, Leslie, Spencer, Brian, Adame, Anthony, Patrick, Christina, Trejo, Margarita, Ubhi, Kiren, Rohn, Troy T., Mueller-Steiner, Sarah, Seubert, Peter, Barbour, Robin, McConlogue, Lisa, Buttini, Manuel, Games, Dora, Schenk, Dale
Publicado em 2011

Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology

Por Bard, Frédérique, Barbour, Robin, Cannon, Catherine, Carretto, Robert, Fox, Michael, Games, Dora, Guido, Teresa, Hoenow, Kathleen, Hu, Kang, Johnson-Wood, Kelly, Khan, Karen, Kholodenko, Dora, Lee, Celeste, Lee, Mike, Motter, Ruth, Nguyen, Minh, Reed, Amanda, Schenk, Dale, Tang, Pearl, Vasquez, Nicki, Seubert, Peter, Yednock, Ted
Publicado em 2003

Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid β-related Behavioral Deficits in a Mouse Model of Alzheimer Disease

Por Basi, Guriqbal S., Feinberg, Hadar, Oshidari, Farshid, Anderson, John, Barbour, Robin, Baker, Jeanne, Comery, Thomas A., Diep, Linnea, Gill, Davinder, Johnson-Wood, Kelly, Goel, Amita, Grantcharova, Katerina, Lee, Mike, Li, Jingzhi, Partridge, Anthony, Griswold-Prenner, Irene, Piot, Nicolas, Walker, Don, Widom, Angela, Pangalos, Menelas N., Seubert, Peter, Jacobsen, J. Steven, Schenk, Dale, Weis, William I.
Publicado em 2010