Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid β-related Behavioral Deficits in a Mouse Model of Alzheimer Disease

Immunotherapy targeting of amyloid β (Aβ) peptide in transgenic mouse models of Alzheimer disease (AD) has been widely demonstrated to resolve amyloid deposition as well as associated neuronal, glial, and inflammatory pathologies. These successes have provided the basis for ongoing clinical trials o...

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Detalhes bibliográficos
Main Authors: Basi, Guriqbal S., Feinberg, Hadar, Oshidari, Farshid, Anderson, John, Barbour, Robin, Baker, Jeanne, Comery, Thomas A., Diep, Linnea, Gill, Davinder, Johnson-Wood, Kelly, Goel, Amita, Grantcharova, Katerina, Lee, Mike, Li, Jingzhi, Partridge, Anthony, Griswold-Prenner, Irene, Piot, Nicolas, Walker, Don, Widom, Angela, Pangalos, Menelas N., Seubert, Peter, Jacobsen, J. Steven, Schenk, Dale, Weis, William I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823416/
https://ncbi.nlm.nih.gov/pubmed/19923222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.045187
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