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Evidence that Enzyme Processivity Mediates Differential Aβ Production by PS1 and PS2
The γ-secretase complex cleaves the carboxy-terminal 99 residue (C99) fragment of the amyloid precursor protein (APP) to generate the amyloid-β (Aβ) peptide. The catalytic activity of this complex is mediated either by the presenilin-1 (PS1) or the presenilin-2 (PS2) subunit. In vitro and in vivo st...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Bentham Science Publishers
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3617584/ https://ncbi.nlm.nih.gov/pubmed/22950863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/156720513804871480 |
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