Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab

INTRODUCTION: Immunotherapy targeting amyloid-β peptide is under active clinical investigation for treatment of Alzheimer’s disease (AD). Among the hypotheses being investigated for impact on clinical outcome are the preferred epitope or conformation of amyloid-β to target for treatment, and the mec...

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Autori principali: Feinberg, Hadar, Saldanha, José W, Diep, Linnea, Goel, Amita, Widom, Angela, Veldman, Geertruida M, Weis, William I, Schenk, Dale, Basi, Guriqbal S
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095729/
https://ncbi.nlm.nih.gov/pubmed/25024748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt261
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