Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity

[Image: see text] Evidence for a central role of amyloid β-protein (Aβ) in the genesis of Alzheimer’s disease (AD) has led to advanced human trials of Aβ-lowering agents. The “amyloid hypothesis” of AD postulates deleterious effects of small, soluble forms of Aβ on synaptic form and function. Becaus...

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Главные авторы: Welzel, Alfred T., Maggio, John E., Shankar, Ganesh M., Walker, Donald E., Ostaszewski, Beth L., Li, Shaomin, Klyubin, Igor, Rowan, Michael J., Seubert, Peter, Walsh, Dominic M., Selkoe, Dennis J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070750/
https://ncbi.nlm.nih.gov/pubmed/24840308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5003053
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