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Effects of secreted oligomers of amyloid β-protein on hippocampal synaptic plasticity: a potent role for trimers
The accumulation of amyloid β-protein (Aβ) in brain regions serving memory and cognition is a central pathogenic feature of Alzheimer's disease (AD). We have shown that small soluble oligomers of human Aβ that are naturally secreted by cultured cells inhibit hippocampal long-term potentiation (...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Blackwell Science Inc
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1779683/ https://ncbi.nlm.nih.gov/pubmed/16469784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.103754 |
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