Soluble oligomers of amyloid β-protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

In Alzheimer's disease (AD), the insidious impairment of declarative memory coincides with the accumulation of extracellular amyloid-β protein (Aβ) and intraneuronal tau aggregates. Dementia severity correlates strongly with decreased synapse density in hippocampus and cortex. Although numerous...

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Hauptverfasser: Li, Shaomin, Hong, Soyon, Shepardson, Nina E., Walsh, Dominic M, Shankar, Ganesh M., Selkoe, Dennis
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702854/
https://ncbi.nlm.nih.gov/pubmed/19555648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.05.012
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