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Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

Soluble oligomers of amyloid β-protein (oAβ) isolated from the brains of Alzheimer's disease (AD) patients have been shown experimentally (in the absence of amyloid plaques) to impair hippocampal synaptic plasticity, decrease synapses, induce tau hyperphosphorylation and neuritic dystrophy, act...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Yang, Ting, Li, Shaomin, Xu, Huixin, Walsh, Dominic M., Selkoe, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214627/
https://ncbi.nlm.nih.gov/pubmed/28053038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1698-16.2016
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