Soluble Aβ Oligomers Impair Hippocampal LTP by Disrupting Glutamatergic/GABAergic Balance

Epileptic activity may be more prevalent in early stage Alzheimer’s disease (AD) than previously believed. Several studies report spontaneous seizures and interictal discharges in mouse models of AD undergoing age-related Aβ accumulation. The mechanism by which Aβ-induced neuronal excitability can t...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Lei, Ming, Xu, Huixin, Li, Zhangyuan, Wang, Zemin, O’Malley, Tiernan T., Zhang, Dainan, Walsh, Dominic M., Xu, Pingyi, Selkoe, Dennis J., Li, Shaomin
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778388/
https://ncbi.nlm.nih.gov/pubmed/26525100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.10.019
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