Soluble Aβ Oligomers Impair Hippocampal LTP by Disrupting Glutamatergic/GABAergic Balance

Epileptic activity may be more prevalent in early stage Alzheimer’s disease (AD) than previously believed. Several studies report spontaneous seizures and interictal discharges in mouse models of AD undergoing age-related Aβ accumulation. The mechanism by which Aβ-induced neuronal excitability can t...

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Bibliographic Details
Published in:	Neurobiol Dis
Main Authors:	Lei, Ming, Xu, Huixin, Li, Zhangyuan, Wang, Zemin, O’Malley, Tiernan T., Zhang, Dainan, Walsh, Dominic M., Xu, Pingyi, Selkoe, Dennis J., Li, Shaomin
Format:	Artigo
Language:	Inglês
Published:	2015
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4778388/ https://ncbi.nlm.nih.gov/pubmed/26525100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.10.019
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Soluble Aβ Oligomers Impair Hippocampal LTP by Disrupting Glutamatergic/GABAergic Balance

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