Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Alzheimer's disease (AD) is characterized by decreased synapse density in hippocampus and neocortex, and synapse loss is the strongest anatomical correlate of the degree of clinical impairment. Although considerable evidence supports a causal role for the amyloid-β protein (Aβ) in AD, a direct...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Shankar, Ganesh M., Bloodgood, Brenda L., Townsend, Matthew, Walsh, Dominic M., Selkoe, Dennis J., Sabatini, Bernardo L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672572/
https://ncbi.nlm.nih.gov/pubmed/17360908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4970-06.2007
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