Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Alzheimer's disease (AD) is characterized by decreased synapse density in hippocampus and neocortex, and synapse loss is the strongest anatomical correlate of the degree of clinical impairment. Although considerable evidence supports a causal role for the amyloid-β protein (Aβ) in AD, a direct...

Full description

Saved in:
Bibliographic Details
Published in:J Neurosci
Main Authors: Shankar, Ganesh M., Bloodgood, Brenda L., Townsend, Matthew, Walsh, Dominic M., Selkoe, Dennis J., Sabatini, Bernardo L.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2007
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672572/
https://ncbi.nlm.nih.gov/pubmed/17360908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4970-06.2007
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items