Axonopathy in an α-Synuclein Transgenic Model of Lewy Body Disease Is Associated with Extensive Accumulation of C-Terminal–Truncated α-Synuclein

Progressive accumulation of α-synuclein (α-syn) in limbic and striatonigral systems is associated with the neurodegenerative processes in dementia with Lewy bodies (DLB) and Parkinson’s disease (PD). The murine Thy-1 (mThy1)-α-syn transgenic (tg) model recapitulates aspects of degenerative processes...

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Autores principales: Games, Dora, Seubert, Peter, Rockenstein, Edward, Patrick, Christina, Trejo, Margarita, Ubhi, Kiren, Ettle, Benjamin, Ghassemiam, Majid, Barbour, Robin, Schenk, Dale, Nuber, Silke, Masliah, Eliezer
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2013
Materias:
Regular Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589076/
https://ncbi.nlm.nih.gov/pubmed/23313024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.11.018
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