Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are common neurodegenerative disorders of the aging population, characterized by progressive and abnormal accumulation of α-synuclein (α-syn). Recent studies have shown that C-terminus (CT) truncation and propagation of α-syn play a r...

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Main Authors: Games, Dora, Valera, Elvira, Spencer, Brian, Rockenstein, Edward, Mante, Michael, Adame, Anthony, Patrick, Christina, Ubhi, Kiren, Nuber, Silke, Sacayon, Patricia, Zago, Wagner, Seubert, Peter, Barbour, Robin, Schenk, Dale, Masliah, Eliezer
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4087215/
https://ncbi.nlm.nih.gov/pubmed/25009275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5314-13.2014
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