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Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of Multiple System Atrophy

Multiple system atrophy (MSA) is a neurodegenerative disease characterized by the pathological accumulation of alpha-synuclein (α-syn) within oligodendroglial cells. This accumulation is accompanied by neuroinflammation with astrogliosis and microgliosis, that leads to neuronal death and subsequent...

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Détails bibliographiques
Auteurs principaux: Valera, Elvira, Ubhi, Kiren, Mante, Michael, Rockenstein, Edward, Masliah, Eliezer
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183229/
https://ncbi.nlm.nih.gov/pubmed/24310907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22610
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